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Chondroitin Sulfate

Chondroitin sulfate is a natural compound found in cartilage, tendons, and ligaments. It may support joint health by promoting joint lubrication, maintaining cartilage integrity, and reducing inflammation. Chondroitin sulfate supplementation is commonly used in combination with glucosamine to improve joint function and reduce joint discomfort.

Chondroitin Buyer's Guide

MODERATE EVIDENCE

Chondroitin sulfate supplements appear to have mild benefits for knee pain and osteoarthritis.

Chondroitin sulfate has MODERATE EVIDENCE for osteoarthritis (PubMed)(PubMed)(PubMed).

Recommended Products

USP Approved Supplements

  • Kirkland Signature Glucosamine with MSM, 375 Tablets
  • Member's Mark Triple Strength Glucosamine 1500 mg & Chondroitin 1200mg Tablets

NSF Approved Supplements

There are no NSF Approved Chondroitin supplements we approve.

Informed Sport Approved Supplements

There are no Informed Sport Approved Chondroitin supplements we approve.

Informed Choice Approved Supplements

There are no Informed Choice Approved Chondroitin supplements we approve.

Other Good Options

  • Life Extension, Glucosamine/Chondroitin
  • NOW Foods, Chondroitin Sulfate
  • Thorne Research, Glucosamine & Chondroitin

Other Options for those with dietary limitations

For Athletes

Verdict: Safe Buy (Non-Athlete)

For athletes, there are no label accuracy and banned substance tested products.

For general use: Chondroitin appears to be effective for osteoarthritis, and may slow progression of degenerative joint disease. Athletes can consider using chondroitin sulfate as a preventative, to preserve joint-health, but the evidence shows only a mild benefit.

Best Product for Athletes

For athletes, there are no label accuracy and banned substance tested products.

For general use, a single-ingredient chondroitin sulfate product we recommend is NOW Foods, Chondroitin Sulfate.

How to take

Take 800 to 1200 mg per day.

Warnings

Appears safe.

For Healthcare Practitioners

Mechanism of Action

Chondroitin sulfate is a glycosaminoglycan. Glycosaminoglycans are complex carbohydrates consisting of long polysaccharides chains of repeating disaccharide units. Chondroitin is hydrophilic, which may contribute to hydration and mechanical support in the joints.

Interactions

Drug Interactions

WARFARIN
Taking chondroitin with glucosamine may increase the effects of warfarin. However, taking chondroitin alone has unknown effects.

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