Although apigenin does appear to have moderate evidence for sleep and anxiety, these benefits are mostly limited to animal studies. Human studies using isolated apigenin may be using a dose that is below the required amount to induce a meaningful effect. Supplements containing apigenin often use amounts that exceed those found in studies for this reason.
There are no USP approved Apigenin supplements.
There are no Informed Choice Approved Apigenin supplements.
There are no options for those with dietary limitations.
Dietary Sources Prefered. Supplemental purchase. Apigenin has benefits for sleep with a good safety profile in men but is not recommended for women, especially women taking birth control or other medications that interfere with hormones. There is evidence that apigenin when isolated in supplement form is less bioavailable compared to dietary sources (PubMed)(PubMed).
Momentous Apigenin is the only product that is approved for athletes and is both NSF Certified for Sport and Informed Sport certified. This means it has been tested for label accuracy and 280+ banned substances. We can’t guarantee a product’s effectiveness unless it has been lab-tested for active ingredients. Momentous Apigenin has been certified to these requirements. Other products on the market lack these required lab-testing results.
For sleep, apigenin should be used 30-60 minutes before sleep.
There is no evidence that apigenin will cause adverse effects when consumed in the diet (PubMed). The dosages used in supplements are low, and at safe levels. However, apigenin does exhibit estrogenic inhibition in women.
Apigenin, is a powerful antioxidant, anti-inflammatory and anti-cancer compound known as a flavonoid aglycone. It is found in high concentrations in dried parsley, and is also present in chamomile, kumquats and artichokes. Chamomile flower is not readily ingested as a food, but in tea form, it confers some apigenin absorption (PubMed).
For anti-cancer effects: Apigenin has anti-cancer effects however the mechanism of action is not well understood and does not appear to extend to human studies. However the dosages (20 mg) used in human studies are low, and given the low bioavailability of apigenin supplements, may not have exposed patients to an effective dose (PubMed). Intervention with apigenin via parsley ingestion increases levels of glutathione reductase and superoxide dismutase (PubMed). Apigenin may target signaling pathways involved in the development and progression of cancer including the Pl3K/Akt/mTOR, MAPK/ERK, JAK/STAT, NF-kappaB, and Wnt/beta-catenin pathways. Apigenin may also regulate the percentage of T killer and T regulatory cells, and modulate PD1/PD-L1 expression in cancer/T killer cells across functions including cell proliferation, metastasis, cell migration, invasion and apoptosis (PubMed).
Parsley, a dietary source of apigenin may interact with the following drugs.
ANTICOAGULANT/ANTIPLATELET DRUGS
Parsley may increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
ANTIDIABETES DRUGS
Parsley may increase the risk of hypoglycemia when taken with antidiabetes drugs.
ASPIRIN
Parsley allergy risk may be increased when taken with aspirin.
DIURETIC DRUGS
Parsley may increase or interfere with the effects of diuretic drugs.
PENTOBARBITAL (Nembutal)
Parsley may increase the duration of pentobarbital effects.
SIROLIMUS (Rapamune)
High-dose parsley may increase Sirolimus levels.
WARFARIN (Coumadin)
High-dose parsley may interact with warfarin to decrease effectiveness.
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